Differential role of dopamine in emotional attention and memory: Evidence from Parkinson's disease
Identifieur interne : 001703 ( Main/Exploration ); précédent : 001702; suivant : 001704Differential role of dopamine in emotional attention and memory: Evidence from Parkinson's disease
Auteurs : Thomas D. H Lbig [États-Unis, Allemagne] ; Stephanie Assuras [États-Unis] ; Judy Creighton [États-Unis] ; Joan C. Borod [États-Unis] ; Winona Tse [États-Unis] ; Pasquale G. Frisina [États-Unis] ; Andrei Voustianiouk [États-Unis] ; Jean-Michel Gracies [États-Unis] ; C. Warren Olanow [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-08-01.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Attention, Attention (drug effects), Basal ganglion, Case-Control Studies, Dopamine, Dopamine Agents (pharmacology), Dopamine Agents (therapeutic use), Emotions (drug effects), Female, Humans, Male, Memory, Middle Aged, Nervous system diseases, Neuropsychological Tests, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Photic Stimulation (methods), Reaction Time, Recognition (Psychology) (drug effects), basal ganglia, dopamine, emotional processing, memory.
- MESH :
- chemical , pharmacology : Dopamine Agents.
- drug effects : Attention, Emotions, Recognition (Psychology).
- drug therapy : Parkinson Disease.
- methods : Photic Stimulation.
- physiopathology : Parkinson Disease.
- chemical , therapeutic use : Dopamine Agents.
- Aged, Analysis of Variance, Case-Control Studies, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Reaction Time.
Abstract
Consistent with the hypothesis that dopamine is implicated in the processing of salient stimuli relevant to the modification of various behavioral responses, Parkinson's disease is associated with emotional blunting. To address the hypothesis that emotional attention and memory are modulated by dopaminergic neurotransmission in Parkinson's disease, we assessed 15 nondemented patients with Parkinson's disease while on and off dopaminergic medication and 15 age‐matched healthy controls. Visual stimuli were presented, and recognition was used to assess emotional memory. Response latency was used as a measure of emotional attention modulation. Stimuli were varied based on valence (pleasant, neutral, and unpleasant) and arousal (high and low) dimensions. Controls had significantly better memory for positive than negative stimuli, whereas patients with Parkinson's disease tested off medication had significantly better memory for negative than positive items. This negativity bias was lost when they were tested while on dopaminergic medication. Reaction times in patients with Parkinson's disease off medication were longer than in healthy controls and, paradoxically, were even longer when on medication. Further, although both healthy controls and patients with Parkinson's disease in the “off” state had arousal‐induced prolongation of reaction time, this effect was not seen in patients with Parkinson's disease on medication. These data indicate that dopaminergic neurotransmission is implicated in emotional memory and attention and suggest that dopamine mediates emotional memory via the valence dimension and emotional attention via arousal. Furthermore, our findings suggest that emotional changes in Parkinson's disease result from the effects of both the disease process and dopaminergic treatment. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23728
Affiliations:
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<front><div type="abstract" xml:lang="en">Consistent with the hypothesis that dopamine is implicated in the processing of salient stimuli relevant to the modification of various behavioral responses, Parkinson's disease is associated with emotional blunting. To address the hypothesis that emotional attention and memory are modulated by dopaminergic neurotransmission in Parkinson's disease, we assessed 15 nondemented patients with Parkinson's disease while on and off dopaminergic medication and 15 age‐matched healthy controls. Visual stimuli were presented, and recognition was used to assess emotional memory. Response latency was used as a measure of emotional attention modulation. Stimuli were varied based on valence (pleasant, neutral, and unpleasant) and arousal (high and low) dimensions. Controls had significantly better memory for positive than negative stimuli, whereas patients with Parkinson's disease tested off medication had significantly better memory for negative than positive items. This negativity bias was lost when they were tested while on dopaminergic medication. Reaction times in patients with Parkinson's disease off medication were longer than in healthy controls and, paradoxically, were even longer when on medication. Further, although both healthy controls and patients with Parkinson's disease in the “off” state had arousal‐induced prolongation of reaction time, this effect was not seen in patients with Parkinson's disease on medication. These data indicate that dopaminergic neurotransmission is implicated in emotional memory and attention and suggest that dopamine mediates emotional memory via the valence dimension and emotional attention via arousal. Furthermore, our findings suggest that emotional changes in Parkinson's disease result from the effects of both the disease process and dopaminergic treatment. © 2011 Movement Disorder Society</div>
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